Biochemistry of signal transduction and regulation / Gerhard Krauss ; translated by Nancy Schönbrunner and Julia Cooper.

Includes bibliographical references and index.

Cover -- Preface -- Overview of Chapters -- Contents -- Chapter 1 The Regulation of Gene Expression -- 1.1 Regulation of Gene Expression: How and Where? A Schematic Overview. -- 1.2 Protein-Nucleic Acid Interactions as a Basis for Specific Gene Regulation. -- 1.3 The Principles of Transcription Regulation -- 1.4 Regulation of Transcription -- 1.5 Post-Transcriptional Regulation of Gene Expression -- Chapter 2 The Regulation of Enzyme Activity -- 2.1 Enzymes as Catalysts -- 2.2 Regulation of Enzymes by Effector Molecules -- 2.3 Mechanistic Descriptions of Allosteric Regulation -- 2.4 Structural Basis of Allosteric Regulation on the Example of Phosphofructokinase -- 2.5 Regulation of Enzyme Activity by Binding of Inhibitor and Activator Proteins -- 2.6 Regulation of Enzyme Activity by Phosphorylation -- 2.7 Regulation of Enzyme Activity by Proteolysis -- Chapter 3 Function and Stucture of Signaling Pathways -- 3.1 General Function of Signaling Pathways -- 3.2 Structure of Signaling Pathways -- 3.3 Extracellular Signaling Molecules -- 3.4 Hormone Receptors -- 3.5 Signal Amplification -- 3.6 Regulation of Inter- and Intracellular Signaling -- 3.7 Membrane Anchoring and Signal Transduction -- Chapter 4 Signaling by Nuclear Receptors -- 4.1 Ligands of Nuclear Receptors -- 4.2 Principles of Signaling by Nuclear Receptors -- 4.3 Classification and Structure of Nuclear Receptors -- 4.4 The Signaling Pathway of the Steroid Hormone Receptors -- 4.5 Signaling by Retinoids, Vitamin D3, and the T3-Hormone -- Chapter 5 G-protein Coupled Signal Transmission Pathways -- 5.1 Transmembrane Receptors: General Structure and Classification -- 5.2 Structural Principles of Transmembrane Receptors -- 5.3 G-protein Coupled Receptors -- 5.4 Regulatory GTPases -- 5.5 The Heterotrimeric G-Proteins -- 5.6 Effector Molecules of G-Proteins -- Chapter 6 Intracellular Messenger Substances: "Second Messengers" -- 6.1 General Functions of Intracellular Messenger Substances -- 6.2 cAMP -- 6.3 cGMP -- 6.4 Metabolism of Inositol Phospholipids and Inositol Phosphate -- 6.5 Inositol 1,4,5-Triphosphate and Release of Ca2+ -- 6.6 Phosphatidyl Inositol Phosphate and PI3-Kinase -- 6.7 Ca2+ as a Signal Molecule -- 6.8 Diacylglycerol as a SignalMolecule -- 6.9 Other Lipid Messengers -- 6.10 The NO Signal Molecule -- Chapter 7 Ser/Thr-specific Protein Kinases and Protein Phosphatases -- 7.1 Classification, Structure and Characteristics of Ser/Thr-specific Protein Kinases -- 7.2 Protein Kinase A -- 7.3 Protein Kinase C -- 7.4 Ca2+/calmodulin Dependent Protein Kinases -- 7.5 Ser/Thr-specific Protein Phosphatases -- 7.6 Coordinated Action of Protein Kinases and Protein Phosphatases -- 7.7 Regulation of Protein Phosphorylation by Specific Localization at Subcellular Structures -- 7.8 General Principles of Regulation of Enzymes by Phosphorylation and Dephosphorylation -- Chapter 8 Signal Transmission via Transmembrane Receptors with Tyrosine-specific Protein Kinase Activity -- 8.1 Struct.

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